Archive for the ‘Vaccinations’ Category

Whooping Cough on the Rise

Friday, July 16th, 2010 by Frank Gillingham, MD

As if budget woes are not enough, last month the State of California officially declared a statewide whooping cough epidemic.  With recorded cases 400 percent higher than last year, including almost 1000 cases in 2010 with five infant deaths, state officials now believe that California is headed for the highest incidence of  pertussis, commonly known as whooping cough, in over 50 years.

California is not alone. The CDC notes that the number of reported cases in the United States tripled between 2002 and 2004.  Although still a far cry from the 175,000 annual cases diagnosed prior to the introduction of the vaccine, the incidence of whooping cough reported annually in the last decade still represents an alarming increase from the less than 3,000 yearly cases in the 1980s.

The dramatic rise in whooping cough is not limited to the United States.  The World Health Organization estimates there were over 17.6 million cases of whooping cough and 300,000 deaths last year alone, making this easily preventable disease one of the world’s leading causes of illness and death. The greatest increase has been in wealthier countries with widespread immunization programs.  The rarity of the illness, coupled with concerns about side effects of the vaccine and the use of vaccines with poor efficacy (Canada, Sweden), has led to an increase in the number of inadequately immunized, or unimmunized children, in developed countries.  In addition, the whooping cough vaccine does not confer lifelong immunity, which means that adults immunized in childhood are susceptible to the illness.  Indeed, almost 25% of whooping cough cases in Europe and the United States are now reported in adults.

Whooping cough is seldom more than a mild inconvenience in those over 10, who may experience prolonged upper respiratory symptoms (runny nose, fever, persistent unproductive cough), but rarely have more serious consequences. Nonetheless, the presence of the B. pertussis infection in adolescents and adults who may transmit the bacteria to infants has led healthcare providers to promote booster immunizations after childhood.  However, booster shots have been approved for adults in only a handful of countries (Canada, France, Germany and the United States), which means that there remains a tremendous reservoir of unprotected adults around the globe, even in developed countries. To compound matters further, there is newly emerging evidence that some strains of the bacteria that cause whooping cough have developed resistance to the newer (acellular) version of the vaccine

Fortunately, the CDC now recommends that anyone traveling outside of the United States receive the DTaP (which includes pertussis protection) vaccine prior to travel. Some resistance notwithstanding, compliance should minimize the risk of contracting the illness overseas and passing it on to susceptible infants who tend to suffer more devastating clinical consequences.

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CDC Updates Dengue and Polio Outbreaks

Friday, June 4th, 2010 by Moira Bishop

Key West, FL has reported 28 cases of dengue fever since July 2009 – prior to July 2009 dengue was absent from the continental U.S. since 1945 and from Florida since 1934. Why dengue has returned to Florida is still being investigated but some contributing factors might be an increase in mosquitoes capable of delivering the disease, an increase in international travel to areas where dengue fever is more common (Key West is, after all, a Caribbean destination — see below), and the popularity of south Florida as a vacation destination.

Travelers headed to Africa, the South Pacific, Central and South America, the Caribbean and Middle East are reminded to take precautions to guard against the mosquito while traveling.  According to the Centers for Disease Control (CDC), a high number of cases of dengue fever, are being reported from the following areas:
Africa
Cape Verde, Senegal, and the Indian Ocean islands of Mayotte and Reunion

South Pacific
Malaysia, Philippines, Singapore, Sri Lanka, Vietnam and the northern parts of Queensland, Australia

Central and South America and the Caribbean
Argentina, Brazil, Colombia, Costa Rica, Dominican Republic, El Salvador, French Guiana, Guadeloupe, Honduras, Peru and Puerto Rico

Middle East
Jeddah (Saudi Arabia)

Meanwhile,the polio outbreak in Tajikistan seems to be spreading to the borders it shares with Uzbekistan.   An additional 261 cases have been reported since our post in early May.  The CDC is reminding travelers headed to these areas to talk to their doctors regarding the necessary vaccinations for children and those previously vaccinated. 

When traveling into any area affected by an outbreak, be smart, protect yourself however you can, and practice good hygiene.

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Vaccinations and Autism – Fact or Myth?

Friday, May 28th, 2010 by Frank Gillingham, MD

A British doctor, whose research linked autism to common vaccines, was stripped of his license to practice medicine earlier this week.  Dr. Andrew Wakefield, whose reports in 1998 found an increased incidence of autism in children who received the measles, mumps and rubella vaccines, and whose study influenced millions of parents to forego vaccinations for their children, was found to have conducted “unethical research.” 

In banning him from practicing medicine in the United Kingdom, Britain’s General Medical Council cited a January ruling that “Wakefield and two other doctors acted unethically and showed a callous disregard for the children in their study.”  Among other indiscretions, Wakefield allegedly paid children for blood samples collected at his son’s birthday party and later joked about the incident.

Despite the fact that numerous other studies failed to corroborate Dr. Wakefield’s results, and that the British journal Lancet eventually retracted the original article detailing his findings, vaccination rates in Britain and other rich countries remain lower than before the study was published over a dozen years ago.  This has led to a number of measles outbreaks in Europe each year and even sporadic cases in the United States. 

Dr. Wakefield has appeared as an expert witness in a number of lawsuits against governments and vaccine manufacturers claiming that the measles, mumps and rubella vaccines led to autism.  Over 5,500 claims have been filed attempting to indict the MMR vaccine, but most have been dismissed for lack of evidence.  Two rulings in March of last year by a special branch of the U.S. Court of Federal Claims found no link between vaccines and autism.

In addition, at least a dozen British medical associations including the Royal College of Physicians, the Medical Research Council and the Wellcome Trust have issued statements verifying the safety of the measles, mumps and rubella vaccine. 

Parents of children who did not receive recommended vaccinations as infants should be aware of the dangers of travelling outside of the United States, and of having close contact with other unvaccinated children who have travelled internationally.  In 2008, a 7 year old unvaccinated boy became infected with measles while traveling in Switzerland.  He unknowingly exposed over 800 people and infected 11 unvaccinated children when he returned to California.  The public health cost for managing the outbreak was almost $200,000!

If you have read this far, I hope you have concluded that the answer to this post’s title is: MYTH.  Were you swayed in the past by these false claims?  How about friends or family members?  Let us know if your opinion on this subject has changed over time and why.  It is important to spread facts and not fiction, at least that’s what we here at the Healthy Travel Blog think.

Photo by firma.

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New Japanese Encephalitis Vaccine Reduces Side Effects

Wednesday, May 19th, 2010 by Guest Author

Good news for travelers throughout Asia.  There is a new vaccine against Japanese encephalitis that significantly reduces typical side effects.

We all know that mosquitoes transmit some very serious viruses to humans. In addition to malaria and dengue fever, another mosquito-driven disease is Japanese encephalitis virus (JEV).  As reported by the World Health Organization (WHO) JEV is endemic in parts of China, India, the Republic of Korea, Japan, the Russian Federation, islands in the Torres Strait of Australia, Nepal, Thailand, Viet Nam, Cambodia, the Lao People’s Democratic Republic, the Philippines, Taiwan, Indonesia, Malaysia, and Sri Lanka. Its breakouts are generally most prevalent during the summer and fall.

There is no treatment available for this disease which can lead to permanent damage to the nervous system or death. Though many vacationers or expats will not find themselves in high-risk areas during peak times, it is recommended by the Centers for Disease Control (CDC) that anyone travelling to an endemic area during a possible transmission season or those who are headed toward a potentially dangerous area should be vaccinated for JEV.

Historically, the vaccine was toxic to some people — especially those with a history of allergy to wasp/bee stings.  Many doctors were hesitant to give the traditional vaccine and if they did, they would advise recipients to stay in a country with decent medical facilities in case they were one of the rare cases to develop an allergic reaction within 10 days of receiving the vaccine.  Fortunately for those over 18 years of age, there is now a new vaccine that does not cause those side-effects and can be given as safely as any of our other vaccines.

In summary: If you are over 18 years old and travelling to one of the high risk areas mentioned above, ask your doctor for the new non-allergic Japanese encephalitis vaccine.

Author: Charlie Easmon, MBBS
Charlie Easmon, MBBS is a General Practitioner whose practice has a strong focus on Travel Medicine.  He is a Regional Physician Advisor for HTH Worldwide and the Medical Director for The Number One Health Group on Harley Street in London and ALC Global Health Insurance.  He is a member of the Royal College of Physicians, UK and has a Diploma in Tropical Medicine and Hygiene from the University of Liverpool.   Dr. Easmon is an Honorary Lecturer at the London School of Hygiene and Tropical Medicine. 

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Mosquitoes – A story of bad news, good news, beer and Malaria

Thursday, March 25th, 2010 by Andy Orr

Two stories concerning mosquitoes caught my attention recently.  In the age-old “bad news, good news” tradition, it goes like this:

“The bad news is that if you drink beer, mosquitoes are more attracted to you and may bite you and give you malaria.  The good news is that scientists have developed a mosquito that could, in theory, vaccinate you against malaria with each bite.”

The first study, Beer Consumption Increases Human Attractiveness to Malaria Mosquitoes, was conducted in Burkina Faso by a team of researchers led by Thierry Lefèvre from Emory University and published by PLoS ONE, an interactive open-access journal.  It concluded that “beer consumption consistently increased volunteers’ attractiveness to mosquitoes.”  The researchers believe that the alcohol in the local beer causes the increased attractiveness; however, further studies are necessary to eliminate other possibilities.  I saw that the local beer is fairly low in alcohol content and wondered what the curve would look like as the strength varied.  Is it a linear relationship, or would it yield an upside-down “U” shape?  If the latter, one could stick to more toxic drinks (although this flies in the face of the researchers who also noted that alcohol consumption has other negative health effects and can lower one’s ability to defend against parasites and other threats to the immune system).  I was lucky enough to learn about the African drink, dawa, from my wife (it was a huge hit on our wedding night).  Dawa means “medicine” or “magical potion” in Swahili and is a much stronger drink than the local beer in Burkina Faso, so perhaps they already know about the shape of the curve.

The second study, Flying vaccinator; a transgenic mosquito delivers a Leishmania vaccine via blood feeding, was published in the April 2010 issue of Insect Molecular Biology and conducted by Associate Professor Shigeto Yoshida and his research team from Jichi Medical University. Unfortunately, there are ethical issues with using wild mosquitoes (are there domesticated ones?) to transmit a vaccine.  How would the pharmas get paid for it, for example?  Oh, yeah, that is not an ethical issue so much as an economical one.  In all seriousness, it does sound like this idea may be years away if it ever gets off the ground (no pun intended).  The mere fact that they did successfully use the mosquito’s saliva to deliver the payload, however, does hold promise for other therapies in the future.

Malaria is a very serious problem worldwide, affecting hundreds of millions of people each year and killing millions, mostly sub-Saharan children.  If you took the time to read this, please think about helping to stop this disease and perhaps contributing to a worthy organization.  It is money well spent. Also, if you are traveling to areas where malaria is a risk, learn about which preventive medicine is right for you and make sure that you take it.

Photo info: http://www.flickr.com/photos/trebol_a/ / CC BY-NC 2.0
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Emerging Antimalarial Drug Resistance – Cause for Alarm

Tuesday, February 9th, 2010 by Frank Gillingham, MD

A report released yesterday by a United States Pharmacopeia program, in partnership with the World Health Organization, cited an increasing level of resistance to Artemisinin – the last affordable drug in the global arsenal against malaria.  The drug resistance is emerging in Uganda, Senegal, Madagascar, Cambodia, Thailand and Vietnam, and is thought to be due in large part to the sale of poor quality versions of Artemisinin in those countries.

The report indicated that between 16 and 40 percent of the drugs marketed as Artemisinin had impurities or did not contain enough active ingredient to be effective.  Drugs will typically lose effectiveness and allow parasites to develop resistance if not given at full strength or for the full recommended course. In the case of malaria, there is no useful replacement for Artemisinin currently available, and many could die or become gravely ill if the current trend continues.

“It is worrisome that almost all of the poor quality data that was obtained was a result of inadequate amounts of active ingredient or the presence of impurities in the product” said Patrick Lukulay, the director of the study.  Senegal had the most disturbing results, with over 40% of the Artemesisin based samples failing quality testing. Lukulay added “There are some countries where donated medicines are not subjected to quality controls, they are just accepted”.  This includes countries in Africa where Chinese products have been given and found later to be unacceptable.

Although results from other countries in the ten country study have not been released, preliminary evidence from the other countries surveyed – Cameroon, Ethiopia, Ghana, Kenya, Malawi, Nigeria and Tanzania suggest that failure rates in at least three of those countries were also high. 

Traditional antimalarial drugs such as malarone, doxycycline, chloroquin and mefloquin are still effective in many parts of the world where the malaria parasite is endemic.  In recent years, Artemesinin has been the last resort in areas where the parasite has developed resistance to these medications. However, for those travelling to sub Sahara Africa or southeast Asia, the risk of contacting Artemesinin resistant malaria is growing.  Although resistance is not yet widespread, it behooves the careful traveler to make sure that any Artemesinin based medication taken for treatment of a malaria infection is of good quality.

Photo info: http://www.flickr.com/photos/lonqueta/ / CC BY-NC-SA 2.0
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Vaccination Recommendations for Travelers

Friday, February 5th, 2010 by Frank Gillingham, MD

In a recent Wall Street Journal post, Avoiding Illness on the Road, Dr. Phyllis Kozarsky, a travel health expert for the Centers for Disease Control (CDC), offered some good advice for travelers, particularly business travelers. 

In this piece Dr. Kozrsky correctly to advises those who are travelling overseas to get immunized, even if coincident with departure.  However, nascent travelers should be aware that protection is not immediate. In the case of the hepatitis A and B vaccines, for instance, full immunity cannot be guaranteed for everyone who receives the vaccine for at least one month.  Long lasting immunity requires a second vaccination anywhere from one month to one year after the first. 

According to the CDC, the only vaccine that is required by international health regulations is yellow fever for those travelling to sub-Saharan Africa and tropical South America. The CDC recommends that this vaccine be obtained at least ten days prior to arriving in an area where yellow fever is endemic.  In addition, the vaccine must be administered at an approved center that can provide the vaccinee an authentic “International Certificate of Vaccination”.  The yellow fever vaccine must be repeated at ten year intervals to remain effective.

Meningitis vaccinations are required in for those travelling to the “meningitis belt” across the middle of the African continent and parts of Saudi Arabia.  The vaccine provides protective antibodies after a week to ten days, with immunization lasting only three to five years.  There are vaccines for encephalitis, an infection of the brain, which must also be administered at least a week or two before travel in order to be protective. 

Those travelling abroad should consult with an infectious disease or travel medicine specialist at least one month prior to trip departure to insure adequate protection against infectious diseases.  Destination specific vaccination requirements can also be found on mPassport.com.

Photo info: http://www.flickr.com/photos/darwinwins/ / CC BY-NC-ND 2.0
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